Articles, Blog

Zombie Cells – David Sinclair’s LIFESPAN

October 12, 2019

at this time but this assuming we’re
able to get it to work we’re gonna be talking about zombie versus senescent
cells this is a an item out of David Sinclair’s book LIFESPAN I’m doing a
series on it as you can see this came out of number 8 on the series
I’m obviously able to do a long series on this book because this channel covers
the same sort of stuff that he covers in the book so I’m having a blast doing
that series we we did publish the the first video on the book I think
yesterday or the day before and the other seven are waiting hopefully I’ll
get another 1 or 2 out of there um but let’s talk about zombie cells before we
do I had a little slide in here to again give you some orientation on on David
Sinclair he’s a PhD longevity researcher he’s tenured at Harvard he started
getting a lot more interest in views one of my had done a video on him gosh 2
years ago and it’s sort of languished didn’t get a lot of views until he
appeared on Joe Rogan experience and Joe Rogan’s got like a gazillion viewers and
anybody that appears there starts getting a lot of views since he’s come
out with the book it’s a very very good book and I expect he’ll continue to get
a lot more attention and focus but let’s go to the book itself so just a brief
overview of the first part of the book he does talk about the hallmarks of
aging he talks about things like how an aging body starts to deregulate nutrient
sensing which is an item it’s an important item but you also get a lot of
other things too loss of proteostasis stem stem cell exhaustion we’ve talked
about that altered intercellular communication
that’s actually a part of the whole zombies cell activity but we’re gonna
discuss the zombie cells a little bit more deeply um again also called
senescent as in old or retired cells he does cover other things epigenetic
alterations and in fact I think the video that came out yesterday was
talking about a theory about aging that he currently claims I think it’s the
most popular theory right now and it makes the most sense it’s called the
information theory it is associated with epigenetic alterations and here’s
the point if you don’t know what epigenetics is it’s the librarian system
of our DNA our genetics just even though I’m 62 now and my body acts a
little bit more insulin resistant a lot more insulin resistance in fact I’ve
actually had a a blood sugar once recorded over 200 so I would fit the
some of the formal definitions of full-blown diabetic anyhow that’s that’s
neither here nor there the point is when I was 20 my body didn’t respond as a
diabetic or even pre-diabetic and yet it is now I still had the same DNA I still
had the same genes but here’s the problem my body’s not accessing those
genes the way it did when I was in my twenties and I’m using myself as an
example I’m no different from any other human that’s what’s going on and he goes
a lot more into depth what he’s what he talks about as a demented pianist
pianist piano player I do have a separate video on that and goes into the
the analogy of what’s going on with again genomic epigenetic alterations
epigenetic failures in the information theory of aging there are the the most
popular theory of aging has had to do with mitochondria mitochondrial theory
of aging started back in the 60s the bottom line is all of these “theories” are actual mechanisms that have plenty of research behind them and I
think what we’re going to find as we get deeper into our knowledge and
understanding of the aging process is that all of these are going on and you
see that in the book he makes no no comments about that either all of these
processes are going on you’ve heard about telomere attrition telomeres are
the caps on the end of the chromosomes they’re somewhat involved with it
significantly involved with epigenetics as well and you began to get loss of the
telomeres is as you age so that’s a little bit of information about the
different types of metabolic processes that go on with aging now you see
this pill bottle over here it’s called Sprycel Dasatinib or Dacatnib it’s
um it’s a medication that has been developed by the folks at Mayo now why
am I showing that that’s actually a medication that clears the body of
zombie cells so like many other things or is there going to become a black
market forward to Dasatinib no not right now and here’s why it’s a fairly
heavy-duty cancer drug and it’s being used for cancer oh let’s let’s we’ll
talk about that in just a minute let’s talk a little bit more about senescent
or zombies cells they were discovered in 1961 macrophages which are a type of
immune cells are more commonly seen as zombie cells but you do see zombie cells
in all tissue types basically what’s going on and here’s why they call it a
zombie cell is the cell is shutting down hmm excuse me the having still a little
bit of allergies that’s been allergy season here for the past couple of
months mine are slowing down some but you’ll again during allergy seasons
twice a year you’ll see me doing a lot of coughing and throat clearing the
zombie cells have shut down some critical processes within the cell one
of them being excuse me epigenetics so that ability to access
DNA now but here’s part of the issue before you start thinking there’s gonna
be a black market for Sprycel to clear out the but to clear zombie cells
out of the body this shutting down of epigenetics actually has a significant
purpose positive purpose in a couple of areas for example it protects the cell
from DNA damage and therefore protects the cell from cancers certain cancers
and again that’s part of what Sprycel is about the the zombie cell process also
is found to has been found to help with healing so there’s still a lot more to
learn about zombie cells but here’s the bad side of them they send out cytokines
and you may remember what cytokines are you break that break down the word don’t
get don’t trip over “cyto” just means cell and “kines” means attractants
so it’s cell attractants so what’s going on is you’re sending out chemical
notices to inflammatory cells to come in and deal with some sort of foreign body
or inflammatory process that is the inflammatory link with zombie cells so
therefore it’s recruiting immune cells to come in and here’s the other
thing if you have a zombie cell in a tissue it tends to recruit cells near it to become zombie cells as well other
people have described these as grumpy retiree
excuse me grumpy retiree types of cells um again they shut down several critical
processes like epigenetics and then they start sending out messages to
neighboring cells to do the same thing into immune cells to come in and start
the inflammatory process Sinclair described the blue
galactosidase stains I think that’s what you see up on the right hand corner and
here’s what happened interesting point the Mayo the researchers it may have
been doing a lot of work with zombie cells they removed these cells in mice
using Sprycel the medication that I showed a picture of a few minutes ago
the mice lived 30 percent longer so again that gives you some perspective of
about Sprycel it’s interesting they’ve gotten some significant
improvements in terms of treatments for certain cancers it’s given for it’s used
now standard of medicine for leukemia certain leukemias but that’s why you’re
not gonna see it a lot of people doing Sprycel supplementation now what is
Sprycel it’s Dacatnib it’s an immunoglobulin but it’s also got a
chemical called Quercetin in it Quercetin is a chemical obtained found
in onions garlic wine green tea so I usually get this question when I talk
about things that are associated with supplements do I supplement obviously
not with rice they’ll wouldn’t try it not not interested in taking that
immunoglobulin but I do I supplement with quercetin not really or no I hope
that I’m getting quercetin from onion scarlet wine and green tea I also do
fasting I do Prolon fasting for about 40 hours once a week that’s a water fast
I do that Monday and Tuesday so I just my last meal is on Sunday evening until
a late lunch early dinner on Tuesday afternoon that as you know those of you
who follow this type of activity that’s work this science know that you get a
lot of other activities besides just zombies cell impact from fasting
especially those of us who have insulin resistance and those of us who have
insulin resistance or full-blown diabetes our outnumber the rest of us
it’s over half of us age 30 and above so last slide on the
topic and then we’ll go back and see if I can manipulate this technology to
where I can see if we’ve gotten attendance and questions so again it’s
cellular aging not organ-related disease as these these three pictures are David
Sinclair on the right and he’s got some bad news for people that are caloric
restriction haters like Jason Fung he likes to say that fasting
is much better in calorie restriction is doesn’t work it does work if you can
maintain it long term at Valter Longo on the bottom he’s the guy you see USC
at Irvine Italian that’s developed Prolon the fasting mimicking
diet he coined the term “juventude” and again the point behind
juventude is that in all of the the gerontology researchers all the
longevity researchers have the same thing it’s this
medicine is built where we go for another couple of years after a dozen
years or more training and then we learn everything there is to learn about heart
disease or we learn everything there is to learn about lung disease and become a
pulmonologist or everything there is to learn about kidney disease and become a
nephrologist etc etc that’s really the wrong way to organize as medicine
because the processes that are killing us start at the cellular level the
biochemical level the genetic level the the epigenetic level so we need to
rethink how we do medicine if we’re going to start doing it the right way
and prevent it in the first place the third the third image there on the left
is Nir Barzilai he’s the principal investigator at Albert Einstein in New
York for the TAME study TAME stands for “targeting aging with metformin” basically
what they’re doing National Institute of Aging and gerontologists they are saying
you know what insulin resistance and diabetes prediabetes are such a core
mechanism of all of these diseases that we’re talking about maybe we should just
put metformin in the water and that’s what the study design for
TAME once people reach a 65 they’re saying half of them go on metformin
and the other half go on a placebo so let’s go back I’m gonna see if see how
we’re doing in terms of the technology and attendees well we do have we did have some folks
that were able to attend it’s hard I can’t see oh yeah we’ve got we’ve got
several folks thanks for attending um just to let you know a couple of things
number one I’m in this different room because we’re trying we’re still working
with the technology you may have some of you may have attended we did a oh
another pilot a trial two days ago again that blew up with the technology so
we’re trying it again we’re changing rooms this gives me two screens
hopefully we’ll be able to get it to where I can actually see comments at the
same time that I’m presenting information right now we can’t do that
I’m still flying a little bit blind applied Michelle and Carl have been
doing some great work to help us get up and rolling so few folks Fil-Am Gabe
good morning Bob Weis good morning RobTO7 yeah good to see you again Rob Terry
Wyatt good morning and I’m glad to see you here
Jeanne Kalahar good morning from Texas well good morning from Lexington
Kentucky Radnally not sure about humans gaining from all this research but mice
but mice are going to be living for decades isn’t that the truth 1957Kato
good morning by the way if you have any questions please go ahead and provide
the questions one thing that we found out with all of our technology
challenges we are going to have to move our routine Wednesday YouTube live and
I’m sure we’re gonna inconvenience a few folks and I apologize it just had to be
we continue to have so many challenges with the technology that in order to
have we need to have co-hosts I cannot operate the switching software and the
YouTube live software and manage the deck and read
questions and answer them all at the same time as you’ve seen I blow it up
too many times and ruin the experience for you guys so I do need to have a
co-hosts Cliede and Michelle this morning and so what we’re gonna do is
it’s going to be 11:00 a.m. Eastern Time instead of 6 p.m. Eastern Time we will
go ahead we plan to present 6 p.m. Eastern time tonight just to warn the
rest of the folks that are that haven’t gotten the message yet and again thank
you for your patience and your interests um
Furius Doe tech works ok now great boy what a relief
that’s been painful Kinpatu this time is better for me than 6:00 p.m. good
morning well Ken thank you very much where are you you’re not where you
locate it Ken James Kantor how much metformin does he give you know what I
was trying to remember that when I looked at that and it’s not the lower
dose it’s not 500 twice a day and it’s not the full 1,000 a day I think it’s
like 750 it may be 800 it’s a good question oh I will let you know though I
just did a recent video on that we’ll have it’s an update here’s the problem
guess what that study at least as of 2019 and Forbes magazine still was not
going on and here’s why the National Institutes of Health has this there’s regulation that they cannot find something unless it’s for a disease well
the guys on the TAME study are clear this is not a single disease this is
multiple diseases in other words it’s aging the NIH has said well we
can’t find something for aging it’s not a disease it’s not classified as a
disease guess how long this has been going on
is it for years I mean it’s like this is so silly one of the questions I have is
well why can’t the guys at on the TAME study just change it and say you know
what we’re just looking at three diseases we’re looking at heart disease
we’re looking at stroke we’re looking at dementia and kidney disease and I don’t
know why I’m not that close to it but it’s just silly I actually um did an
update on it and thought it had been funded about a year ago
and sure enough AMFAR the American Foundation for Aging Research had funded
it about a year ago but here’s what else I found out I thought it was going once
they’ve got funding here’s what else I found out the AMFAR only funded like 15
million they needed another 25 million and again they’re still AMFAR is waiting
for the NIH and the NIH isn’t budging so you know you would think that human
lives might be a little bit more important than that but anyway if
somebody now if somebody how many millions are they spending on getting
stress tests okay and Furius Doe greets from Holland very good you know one of
the things I thought about Furius Doe and we had to make this time changes
that we may be able to get more English folks in maybe I was confused on my time
but and you either way glad to have it Furius though the rest inflammation
comes later I am fasting and trying to activate activate my kidney well thanks
for sharing that Bob Weis do we get notified in advance of transmission yes
yes you do now what you have to do is I’m wondering if I can go in when you
when you subscribe to our channel there’s a little bell icon
click that bell icon twice because if you just click it once the it’s pretty
clear they only notify you have about 10 percent of the videos that are coming up
if you get it twice you should start getting notifications even on the lives
the live events Kinpatu in Atlanta very good thanks for sharing that
Terry Wyatt signed up for your webinar and getting my labs done Monday could
not afford not to do it thank you for your for the help and thank you so much
for the comment Terry as and as I’ve shared with multiple people many of my I
mean I’ve been doing prevent these a higher level type of preventive
evaluation for years and many of my clients are these guys that again
multimillionaires on their own plane can afford ten fifteen thousand dollars for
this kind of work and sure enough you see that at places like the Four Seasons
California Institute of Longevity but what you get is some really good hotel
accommodations and spine and that kind of stuff and you get docs that are gonna
do it again a stress test and talk with you about it I’ve never included routine
stress test as part of my evaluations I’ve always had them less expensive five
thousand was the most that we’ve had them we still have more of that level of
evaluation but my passion has been to get it accessible to people that don’t
own their own airplanes so we continue to work over and over and more and more
to get the essence preventive services for people for less and the webinar is a
is a major a major step forward in that way actually thank you Terry for
bringing that up and what I’m going to do is use this as an opportunity to talk
a little bit more about the webinar itself because what we’re doing with
webinars you can get some of the essence of a critical preventive medicine
screening program for less than 500 bucks right now it’s still like $299
for the next I think half a dozen people let me cover that before we do I will
let you know this channel obviously most of the information that I’ve provided
has tended to be technical so I get a lot of docs I get a lot of dentists at
one time about excuse me about half of my patients and viewers were dentists
and we can go into some detail on that it’s the thing is when you have bleeding
gums be very afraid even if they only bleed when you go to the dentist that’s
clearly a sign of arterial inflammation and a lot of dentists know that and
that’s why they get focused on this stuff let me just show you this this
screen for a minute speaking of geeks this actual we’re like
this this is my wife by the way Janice has been on a few of our videos she’s
our health our health coach this image is showing where we’re starting to take
a look at getting folks that are non-geek that are not into bio-indicators
biomarkers senescence cells that sort of stuff but just want to prevent their own
heart attack or stroke or kidney disease or dementia you’ll start seeing that we
glad started doing a lot of work on that this week to get that in Facebook
campaigns so just to make you aware and again as you’ll start seeing that
Facebook campaigns some of the Facebook videos are the same videos that you see
on YouTube but a lot of these you’re going to be again hitting for John Q
public now you can go into our membership page it now has a big
statement about the webinars if you haven’t been into the membership
page everything that we’re offering is located on that membership page you get
infographics course and book reviews free review of the upcoming book that
book actually will show you why I make disparaging comments about about stress
tests it gives you registration options for the webinar CIMT event
registrations and the boot camp event for Louisville registration for their how do
you get to the membership login page well if you go to the website there’s a
new button right here membership login you go in you create a free account
again you’ll see there little bit Louisville event registration the
Anaheim event the first CIMT Access event in Anaheim LA David did it is very
successful we had about three dozen people come in and get their CIMTs
now the webinar series again what I believe is Terry Wyatt and brought up
the webinar series is again our most recent focus on trying to make
world-class prevention available for people that can’t afford their own
airplane for much more reasonable implement dollars here’s how this came
up in our inflammation course we we had a video where we talked about and I’ve
done done several videos on how to get labs on your own and it was the
inflammation panel well what we found was that was now outdated you can’t go
to Quest now and do a patient-directed inflammation panel well you can through
us and I said you know what what we’ll do is open it up to where patients can
get the inflammation panel through us so here’s what the webinar is it’s
people are getting confused and we’ve marketed it completely wrong we’d call
it a webinar it’s like marketing a car by saying here this
is a trunk that we’re selling here’s what we’re making available we’re making
lab tests the inflammation panel includes C-reactive protein
myeloperoxidase (MPO) PLAC2 and microalbumin-creatinine ratio we’re
also making the OGTT available it’s part of this $490 cost you fast
for 8 hours before you come in you you get a blood sugar and an insulin to
start base blood sugar basal insulin then you take that Glucola the 75
grams of glucose in a cola an hour later you get another glucose another insulin
level and then an hour later you get another glucose another insulin level
you get all of those labs included in that price plus your you can attend the
webinars private webinars with me over the net over the next three months and
we go over results so a lot of good information out of that and again I will
go back and see what sort of comments questions we have Kinpatu lives in
Atlanta thanks Ken 1957Kato so should we go and take metformin I do
David Sinclair started in his 40s and I do make it available we if you have you
have I heard of about berberine yes I take berberine as well a lot of people
do berberine has some of that effect Venu Gopal
this K2 MK7 really helped and nobody knows there’s clearly evidence that it
does I have started taking it again I looked at the original clinical trials
on K2 and the kind of some of them are good sometimes some of them show
evidence some of them don’t the the only one that really shows
significant evidence is the Rotterdam trial and the question is is that enough
to prove that there’s something going on the answer is no it doesn’t really prove
it it’s not clear at this point but there’s a lot of other interesting
information about osteocalcin and a couple of other enzymes that not only
are carboxylated in other word is activated by K2 they also are very
much related to insulin resistance so it may be another one of those things
called pleiotropic effects excuse me pleiotropic meaning
impacts different several different places several different perspectives
Furious Doe there was a Dutch TV program about Valter I think you’re not
saying Valter Longo that lunch hospital is
having great progress using fasting on cancer and inflammation that was
actually the origin of the Prolon fasting mimicking diet
Longo was not trying to come up with a new type of diet what he was trying to
do was mimic fasting there is incontrovertible evidence that fasting
works pardon me I keep me to keep these own in order to get guidance from Cliede
and Michelle there regarding the science on K2 as I said that’s iffy it’s not
proven there’s no question about fasting it is it does work in many many places
many ways but here’s the problem that long ago had you’ve got a doc you’ve
got an oncologist a cancer doctor the patient is wasting away from
combinations of the cancer chemo and radiation therapy and then you ask them
to fast the patient they just they could not get their head around it that was
what led to the fasting mimicking diet so it’s good good point thank you for
bringing it up Joe Engers from Sydney Australia thanks Samier6
greetings from the Philippines Samier Cliede is in the Philippines and he
and I have talked about starting to provide more resources in the
Philippines Farrokh Farr I’ve seen you quite a
bit front thanks for your comments and your interest hello good doctor from
Iran hello glad to have you James Kantor K2 MK7 hundred micrograms seemed to help
gum bleeding for me that’s interesting thanks for sharing that James
S55b do you schedule for your future events coming
to Florida soon we do have a tentative plan to come somewhere near Orlando in
the January February time frame Michelle’s working on that I’m sure she’s
rolling her I’m rolling her eyes right now saying you know what this is too
much but that’s what we’re planning I’ve got a couple of friends in Orlando
David Meinz lives in Orlando he’s helped us with a couple of events he
actually did the CIMT event in Anaheim we’ve got a fellow that’s done a couple
of videos with us his name is Chuck Smith Chuck has a company and actually
on his video he showed he lost 50 pounds on a vegan diet with a Dr. Esselstyn
which you’ve probably heard of um after that he had a heart attack and again he
shared that on the video he started looking obviously that was frustrating
so he started looking at at channels like mine and he and he noticed the
triglyceride/HDL ratio so he noticed that his was 5 at even losing 50 pounds
because he was getting too many carbs from the vegan diet are not getting and no
offense you can go completely low carb completely ketogenic on a vegan diet but
you have to know what you’re doing and he was not focused on that at that point
since then he’s gotten his triglyceride/HDL down to about 1 he’s
got a lot of interest he lives in that area and he’s got a lot of folks he
would like to bring to an event so we’re working on getting an event in Orlando
hopefully January February hopefully Michelle will be able to keep us updated
on that James Kantor dental hygienist said gums
were better – very glad to hear that RobTO7 hello doc if after a few months
on atorvastatin 40 if someone’s LDL dropped from 120 to 47 would you still
recommend switching to rosuvastatin great question RobTO7 in the
answer is yes I would and here’s why we talked about pleiotropic activities
when we’re talking about K2 a pleiotropic activity is you give it for one
thing but it actually helps on something else here’s what happens with statins
mostly statins are given to lower LDL but think about the logic and I know
you’ve seen a lot of our videos I’ve seen you around a good bit in terms of
your comments half the people that have a heart attack have a normal LDL so is
it really LDL that’s causing this probably not on the other hand there’s a
big thing in terms of inflammation I’m not going to go down that trail right
now but there’s a very smart guy named Paul Ridker at Harvard who noticed this
over a decade ago that whether people’s LDL was low or high quite often if
they’re on statins they still had a significant decrease in heart attack and
well if they’re on statins they had a significant heart attack risk he
theorized that was due to inflammation and that in that science has been proven
out multiple times why did I go down that path because here’s the problem
people are still taking atorvastatin Lipitor watching their LDL and
thinking they’re getting a good impact Lipitor is the least likely of all of
the statins to impact inflammation it still does but here’s two things if
you’re a female it’s less likely and if you have insulin resistance it’s less
likely over half of us are have insulin resistance or diabetes and half of us
are females so and in the by far the biggest prescription given in the satin
areas is Lipitor so from that perspective I would say a huge portion
statin prescriptions are doing more damage than they’re then they’re helping
so I hope that answers your question Venu Gopal James Kantor any side
effects or palpitation uh James Kantor no no palpitations
still working to get blood pressure down statins may cause diabetes is it true
actually that’s a very good point statins will push you down that insulin
resistance highway all of them except one mm-hmm
and that one is very expensive it’s called pitavastatin
has not broke and has not lived through it some oh god it’s a patent yet so
again very expensive we didn’t use it for the first couple of years it was out
because it wasn’t clear that it had that pleiotropic effect of decreasing
inflammation the research is out now out pitavastatin or Livalo does decrease
inflammation and here’s what else it actually it’s the only statin now that
that decreases insulin resistance as well so I had so the final barrier is
cost I had a patient who was on Livalo who found a great price at a
Canadian online pharmacy he shared that with other patients at the event this
past March in Orlando they all wanted to go that route so that I’ve got dozens of
people now on on Patera stanton from canadian online pharmacy so again it’s
getting that the midea we’re getting on into 40 minutes I want to try to start
keeping these a little bit lower shorter a little bit more like half an hour so I
really appreciate your interest those of you have joined and again just be aware
we plan to do a short one again tonight to let the six o’clock folks know but
we’ll be moving to the 11:00 a.m. time frame thank you again for your interest


  • Reply Nezar BD October 9, 2019 at 4:01 pm

    Keep up the great work!😊👍
    love from Bangladeshi Jr.PUBG/COD player 👉🇧🇩👈

  • Reply amer Al Gayar October 9, 2019 at 4:53 pm

    Thank you for the wonderful videos

  • Reply Daniel Christopher October 9, 2019 at 5:05 pm


  • Reply strings41 October 9, 2019 at 6:27 pm

    In today's newspaper there is a fairly large ad for an oral spray called CELLTRIM. Among other things, this spray supposedly reduces blood sugar level by as much as 27%. It's OTC. Have you heard of this? Thanks for your informative vids.

  • Reply 147DegreesWest October 9, 2019 at 7:32 pm

    Great video!

    I wondered if you had changed the time! I set my phone alarm for your lives- and I happen to see this when I was taking my Levothyroxin. Sorry I missed it today- will change the schedule.

  • Reply Dave Oatway October 9, 2019 at 9:31 pm

    The ingrained institutional bias in the peer review process has made any proposal to the Institute of Aging that does not address Alzheimer's a non-starter. They want to keep the funding in their community. I was on a NIH proposal review committee years ago (not Aging), and suspect the process hasn't changed. The same thing is probably happening with the dietary guidelines. At lest for the dietary guidelines Congress has finally mandated that recommendations must be science based. We will see next year.

  • Reply Loretta Dillon-Ham October 9, 2019 at 10:24 pm

    Wahhhhh!!!!! I missed this. 7 hours ago was 1:00 am in the morning 😭😞

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